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KMID : 0369819950250020153
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Jorunal of Korean Pharmaceutical Sciences
1995 Volume.25 No. 2 p.153 ~ p.161
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Sustained Release of Ibuprofen from Sodium Alginate Beads
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Abstract
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Alginic acid is ahydrophilic, colloidal polysaccharide obtained from cell wall of seaweed of brown algae and has a broad range of applications. Alginic acid becomes alginate gel bead due to its cation-induced gelation. Dried alginate beads can be
reswollen according to environmental pH. The purpose of this paper is to explore the possible applicability of alginate beads as an oral controlled release system of ibuprofen. In thisexperiment ibuprofen was incorporated in alginate beads and
alginnate
beads were treated with various methods. Ibuprofen releasefrom alginate beads in phosphate buffer (ph 7.4) was faster than in distilled water and dilute HCI. The release of ibuprofen was more sustained in bead than simple mixture and
coprecipitate
of
ibuprofen and sodium alginate. The dissolution rate of ibuprofen was decreased in using of bead that hardened with formaldehyde. The dissolution rate of the drug from the bead was the fastest in 12 hor dried beads. 1.5%-sodium alginate
concentration and
1%-calcium chloride concentration. Sodium alginate bead can be used as a sustained release drug delivery system of water-insoluble drugs.
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